EatCoconut RiceNotices to be taken into account

1 Hydroxyl aluminum, magnesium oxide or metoclopramide (Ganfu'ansi) used concurrently with this product can reduce its blood concentration.BloodDrug concentration decreases.

2 May lower the efficacy of sul.

3 This product is a liver enzyme inhibitor.Used with propranolol, it increases its serum concentration, slowing heart rate at rest;Used with phenytoin or other drugs, may increase their blood drug concentration, leading to phenytoin poisoning.

4 Used with opioids, reports of respiratory depression, confusion, and loss of orientation have been observed in patients with chronic renal failure.

5 Increases the absolute bioavailability of verapamil (Isoptin). As this can cause rare but severe side effects, it requires attention.

6 With, reduces its demethylation clearance by 20-30%, raising its blood concentration.

7 Used with benzodiazepines, may increase the blood concentration of diazepam and other central nervous system depressants, potentially leading to respiratory and circulatory failure.

8 Combining this product with digoxin and quinidine is not advisable as it can inhibit the metabolism of quinidine, displacing digoxin from its binding site, resulting in increased blood concentrations of both drugs.

9 Can delayCaffeine'sDue to the metabolic effects, this interaction may enhance the latter's action and increase the risk of toxicity.

10 Used with warfarin-like anticoagulants, it can decrease their excretion rate, leading to an increased tendency for bleeding.

11 With tetracycline, it decreases its dissolution rate and absorption, reducing its efficacy;While aspirin has the opposite effect.

12 Used with ketoconazole, it interferes with its absorption, reducing its antifungal activity; however, co-administration with some acidic beverages can prevent these effects.

13 Combined with captopril may cause psychiatric symptoms.

14 Due to the neuromuscular blocking effect similar to aminoglycosides, this cannot be antagonized by neostigmine but can be reversed by calcium chloride.Thus, combined use with aminoglycoside antibiotics may lead to respiratory depression or arrest.